Prognostic Value of the Uric Acid Level and Its Effect on Survival in Stage I–III Gastric Cancer

Abstract

BACKGROUND/AIMSUric acid is the product of purine metabolism. In this study, we investigated the prognostic value of serum uric acid value on disease-free and overall survival (DSF and OS) in gastric cancer.MATERIAL and METHODSThe records of 110 patients who underwent surgery for Stage I–III gastric cancer between 2012 and 2014 were retrospectively analyzed.RESULTSThe average follow-up period was 42 months in 110 patients studied. The mean age was 63.7±11.6 years. Seventy percent of patients were male, and 43% underwent total and 57% subtotal gastrectomy. Most of gastric tumors were located in the distal stomach (56%), 24% in cardia, and 19% in corpus. While the tumor size was found to be larger than 4 cm in 60% of the patients and larger than 8 cm in 20%, according to the TNM system, 11% were Stage I , 29% Stage II, and 60% Stage III. Metastatic/excised lymph node ratio is <0.3 in 59% of patients. The mean uric acid level was 4.63±1.44. The cut-off values of uric acid were studied as 4 and 6.CONCLUSIONWhen the mean distribution of the OS and DFS values according to uric acid groups was examined, there was no statistically significant difference between the groups (p>0.05). In our study, while the uric acid value was not found to be effective in DSF and OS, the stage, metastatic lymph node ratio, tumor size, and localization were found to be effective factors in OS.