An Overview of Ischemia-Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response

Abstract

Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia-reperfusion. There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1 ss, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa ss, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.