Mixed Adeno-Neuroendocrine Carcinoma; Case Series of Ten Patients with Review of the Literature

Abstract

Aims: Mixed adeno-neuroendocrine carcinoma is a rare entity,diagnosed with immunohistochemical studies. Literature mainlyincludes case reports and series which are very few. In our study, weaimed to report a case series from a tertiary hospital with demographicsof the patients, detailed tumor and clinical findings and follow-up plussurvival conditions.Methods: Pathology database was explored for patients with thepathological diagnosis of ‘mixed adeno-neuroendocrine carcinoma’and patients were identified retrospectively and evaluated in meansof demographics, histopathological examination, tumor properties.Results: Ten patients had been diagnosed with mixed adenoneuroendocrinecarcinoma in our center, diagnosed at a mean age of64.7. Stomach was found to be the most common localization. Fivepatients (50%) were diagnosed as grade 3. Following surgery, medianfollow-up was 15 months with a median survival time of 20.6 months.Conclusion: This case series may contribute to the literature on thepathological and clinical aspects of the mixed adenoneuroendocrinecarcinoma of the gastrointestinal system.