Evaluation of hematologic and coagulation system disorders in adolescents with polycystic ovary syndrome

Abstract

Aim: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction, insulin resistance, and obesity, affects 8-26% of adolescent girls. The effects of polycystic ovarian syndrome on the hematologic and coagulation systems have received little attention. We aimed to investigate the hematologic and coagulation system disorders in PCOS. Materials and Methods: The study included 40 adolescents with PCOS and 41 healthy controls. Hemostatic and coagulation system parameters evaluated in both groups and were compared with metabolic parameters. Results: Adolescent’s with PCOS had a significantly higher insulin, HOMA-IR levels, and Hematocrit (Hct) levels than the control group, but no significant difference was found in D-dimer, fibrinogen, protein C, protein S, Antitrombine III levels. A positive correlation was found between insulin and HOMA-IR values and hemoglobin (Hgb), Hct, white blood cell (WBC) levels (r=0.32 p=0.003; r=0.33 p=0.002; r=0.36 p=0.001, respectively); also a positive correlation was found between high-density lipoprotein cholesterol (HDL) and WBC values (r=0.26 p=0.01). A positive correlation was found between follicle stimulating hormone (FSH) and Protein C and Protein S (r=0.41 p=0.008; r=0.31 p=0.04); total testosterone and fibrinogen levels (r=0, 32 p=0.04); Dehydroepiandrostenedione sulfate (DHEAS) and protein S levels (r=0.31 p=0.04). Conclusion: There was no significant difference in the hematologic and coagulation parameters between PCOS and healthy controls. Hypercoagulated state in PCOS is associated with obesity, BMI, inflammation, and insulin resistance, not specific to the disease.