An interesting case of refractory hypotension and noncardiogenic pulmonary edema after amlodipine overdose

Abstract

Amlodipine is a dihydropyridine calcium channel blocker that acts on intravascular L-type calcium channels. It is most effective on vascular smooth muscle cells and has little effect on cardiac tissue. Its most common use is hypertension, angina, arrhythmias, subarachnoid hemorrhage, migraine, and Raynaud's disease. Amlodipine is preferred because it is used once a day and has minimal side effects on heart rate. However, in case of acute overdose, either accidental or deliberate (e.g., suicide attempts), dangerous side effects may occur and may result in death. Herein, we presented a 34-year-old male patient who ingested 90 tablets of amlodipine 10 mg and was successfully treated.