The role of HDL-related myeloperoxidase (MPO) and paraoxonase 1 (PON1) in terms of coronary artery disease in Hashimoto’s thyroiditis

Abstract

Hashimoto’s thyroiditis (HT) is an autoimmune disease of the thyroid gland. Free radicals have been reported to be responsible for the complications observed in the pathogenesis of thyroid diseases and the later stages of the disease. Myeloperoxidase (MPO), which is released from neutrophils during inflammation and oxidative stress and causes cell destruction, is a marker that plays a role in the development of cardiovascular disease associated with oxidative damage in the arterial wall. Paraoxonase-1(PON-1), which is one of the molecules that play a role in oxidant balance, is an enzyme that inhibits lipoprotein oxidation by hydrolyzing lipid peroxides in oxidized low-density lipoprotein(LDL) structure. We investigated the role of HDL-associated MPO and PON-1 in patients with HT in terms of coronary artery disease. Our study group consisted of 54 patients with Hashimoto’s diagnosis and 50 healthy individuals in the control group.MPO and PON-1 levels were determined spectrophotometrically. When the study groups were evaluated, MPO levels were significantly higher in patients with Hashimoto thyroiditis than in the control group (p < 0.05, p = 0.001). A negative correlation was obtained between MPO and PON-1 (r = ? 0.685). The decrease in PON-1 activity and increase in MPO activity due to the hypothyroid effect increases lipid peroxide formation and accelerates oxidized LDL formation, which leads to a decrease in antioxidant capacity and the development of atherosclerosis. Since oxidative stress in thyroid diseases is also responsible for the complications observed in the later stages of the disease, we think that important data were obtained with this study in terms of both diagnosis and treatment. © 2023, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.