The Association Between Atherogenic Index of Plasma and No-Reflow Phenomenon in Acute Coronary Syndrome

Abstract

Background: The atherogenic index of plasma (AIP) is a biomarker of plasma atheroge- nicity. Elevated AIP is linked with adverse cardiac events. We sought to examine the asso- ciation of admission AIP and no-reflow phenomenon (NRP) in acute coronary syndrome (ACS) patient population treated with percutaneous coronary intervention (PCI). Methods: Eight hundred eight-four ACS patients were included to statistical tests retro- spectively and classified according to the occurrence of NRP: NRP (?) (n = 662) and NRP (+) (n = 186). AIP levels were calculated through the formula log10 (triglyceride-to-hig h-density lipoprotein cholesterol ratio). Results: AIP levels were higher in NRP (+) patients compared to NRP (?) group patients. The receiver operating characteristic (ROC) curve analysis for AIP to predict NRP yielded an area under the ROC curve value 0.643 [95% confidence interval (CI): 0.596-0.690, P < .001]. AIP was associated with NRP in univariate logistic regression analysis [Odds Ratio (OR): 2.46; P = .001; CI: 1.44 (lower limit)-4.21 (upper limit)]. However, AIP did not emerge as a significant prognostic factor of NRP in multiple logistic regression analysis [OR: 2.11; P = .422; CI: 0.34 (lower limit)-13.11 (upper limit)]. On the other hand, peak troponin T (log10) was an independent prognostic factor for NRP [OR: 0.13; P < .001; CI: 0.10 (lower limit)-0.37 (upper limit)] occurrence. Conclusion: The AIP level on admission is not a statistically significant prognostic factor of NRP. However, peak troponin T (log10) is an independent prognostic parameter of NRP.