The Effect of Neutrophile Lymphocyte Ratio (NLR) on Disease Free Survival (DFS) and Overall Survival (OS) In Gastric Cancer and its Relation with Clinicopathological Features

Abstract

Objectives: Neutrophile-lymphocyte ratio (NLR) is an inflammatory marker and has prognostic significance for manycancers.In this study, we evaluated the prognostic value of NLR ratio and its relation with clinicopathological featuresin gastric cancer.Methods: A retrospective review of 110 patients who underwent stomach cancer surgery between 2012 and 2014 wasperformed electronically.Results: The mean age was 63.7±11.6 years.Seventy percent of the patients were male and 43% underwent total and57% subtotal gastrectomies. According to TNM staging; 11% were in stage 1, 29% in stage 2 and 60% in stage 3. Metastatic/total lymph node ratio is below 0.3 in 59% of patients. Neutrophil/lymphocyte ratio was found to be greaterthan 2.5 in 50% of patients and greater than 3 in 33% of patients. The mean NLR value was 3.38±2.7 (1.09-19.1).Conclusion: In our study, while NLR was not detected as an effective factor on disease-free survival; stage, metastaticlymph node ratio, tumor size and localization were found as independent factors effective on overall survival. As a significant factor in multivariate analysis, NLR reflects the immune status of the organism, not the tumor aggressivenessor stage and it is an independent prognostic factor.