Evaluation of Dermatological Lesions in Patients With Hematologic Malignancy

Abstract

The purpose of this study was to assess dermatological lesions in hematologic malignancy patients. Patient file records pertaining to patients diagnosed with hematologic malignancies and followed up in our center between 2019 and 2024 will be retrospectively examined for demographic information, hematologic disease diagnoses, clinical features, dermatological examination data obtained with dermatology consultation, pathology results of biopsies taken from skin lesions, and the presence of other malignancies. The study comprised 241 participants with hematologic malignancies. The male to female ratio was 1.3, and the median age was 64. Acute myeloid leukemia (AML) accounted for 24.1% of diagnoses, while multiple myeloma (MM) came in second with 18.3%. With a rate of 14.9%, dermatitis was the most frequent form of lesion, followed by drug response (14.5%). In the AML group, dermatitis and fungal infection were the most frequent lesions, while in the MM group, medication reactions were more common. Patients with malignancy experienced urticaria considerably more frequently (p=0.004). At the time of lesion development, 81.7% of the patients were receiving chemotherapy, with alkylating drugs being the most frequently utilized agents (24.9%). Twenty percent of individuals who had biopsies reported having vasculitis and drug-related dermatological responses. 98.8% of the patients received local/topical supportive treatments without stopping systemic treatment. According to this study, dermatological lesions in hematologic malignancies may be connected to the course of the disease as well as treatment. These results imply that routine follow-up for hematologic patients should include a dermatological evaluation. © 2026, Bursa Uludağ University Faculty of Medicine. All rights reserved.