Early Period Impact of Renal Function Changes Following Renal Transplantation on Optical Coherence Tomography Disc Parameters

Abstract

Purpose: It was aimed to investigate the changes in optical coherence tomography (OCT) disc parameters, intraocular pressure (IOP) and mean blood pressure (MBP) measurements of the patients underwent renal transplantation with the diagnosis of end-stage renal failure and to evaluate their relationship with the glomerular filtration rate (GFR). Materials and Methods: This retrospective study included right eyes of 36 patients. wereisIn addition to the findings of ophthalmologic examination; OCT disc parameters obtained using Zeiss Cirrus OCT (CIRRUS™ HD-OCT 5000) device, cubital blood pressure values, GFR values and IOP measurements were evaluated before the transplantation surgery (baseline) and at the end of postoperative month 1. Postoperative renal function was assessed using GFR. was The effects of renal function on OCT disc parameters, IOP measurements and MBP values were evaluated. Results: There were 20 women and 16 men in the study. The mean age was 28.10±8.25 years. There were no significant difference in MBP and mean Retinal Nerve Fiber Layer (RNFL) thickness between baseline and on postoperative month 1 (p=0.21;p=0.85 respectively). Mean IOP value was 14.11±2.20 mm-Hg at baseline and 13.95±3.02 mmHg on postoperative month 1, indicating no significant difference (p=0,55). The GFR was 8.15 mL/min/1.73 m2 at baseline and 66.3 mL/min/1.73 m2 on postoperative month 1, indicating significant difference u(p<0.001). Conclusion: Despite the fact that there is a significant difference in between GFR values after renal transplantation surgery, no significant difference was detected in OCT disc parameters was not before and after transplant surgery. This study demonstrated that renal function does not have an effect upon OCT disc parameters. © 2022, Gazi Eye Foundation. All rights reserved.