Evaluation of mean platelet volume in patients with different degree of coronary collateral development

Abstract

Aim: Coronary collateral vessels are an alternative source of blood supply to a myocardial area jeopardized by ischemia. As some patients have poor collaterals despite significant stenosis, it is thought that multiple factors affect collateral development beside coronary artery disease severity. Mean platelet volume is an indicator of platelet activation. Increased mean platelet volume is found to be related to worse prognosis in the coronary artery disease. In this study, we aimed to investigate the relationship between mean platelet volume and coronary collateral development. Material and Method: Patients with total occlusion in at least one coronary artery were enrolled in this study. Coronary angiography images of 367 patients without a history of revascularization were evaluated retrospectively, and coronary collateral development was graded according to Rentrop classification. Patients were divided into two groups based on Rentrop classification. Rentrop grade 0-1 was regarded as poor collateral development, and Rentrop 2-3 was regarded asgood collateral development. Mean platelet volume was compared between these two groups. Results: Poor collateral development was found in 236 patients (64.3%), and good collateral development was found in 131 patients (35.7%). There was no statistically significant difference in mean platelet volume levels between two groups (9.9 +/- 1,2 fL and 10.3 +/- 1.3 fL p=0,228). The 3-vessel disease was found to be a predictor of good collateral development (p= 0.024). Discussion: In this study, it was found that there was no relationship between mean platelet volume and coronary collateral development.